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C. pneumoniae Infection in Atherosclerosis

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Description

Atherosclerosis, the pathological basis of CAD (Coronary Artery Disease) and Ischemic Stroke, is the commonest cause of death and disability in the western world. Atherosclerosis is a multifactorial, highly complex disease with numerous aetiologies simultaneously and sequentially collaborating in subtle ways to affect lesion development, progression and maturation to an advanced, disease-provoking entity (Ref.1). The lesion, or Atheroma, is an inflammatory site composed of a necrotic lipid-rich core, modified vascular endothelium, SMCs (Smooth Muscle Cells), foamy macrophages, lymphocytes and a variety of inflammatory mediators. Inflammation is the key event in Atherosclerotic Plaque fissuring and rupture, causing adverse clinical events. A variety of risk factors are known to be associated with the pathogenesis of Atherosclerosis. These include genetic and lifestyle factors [...]

References:

1.Chlamydia pneumoniae and atherosclerosis.
Belland RJ, Ouellette SP, Gieffers J, Byrne GI.
Cell Microbiol. 2004 Feb;6(2):117-27.
2.Chlamydia pneumoniae and atherosclerosis -- what we know and what we don't.
Ngeh J, Anand V, Gupta S.
Clin Microbiol Infect. 2002 Jan;8(1):2-13.
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