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CCKBR-Gastrin Stimulated Signaling

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Description

Multicellular organisms have developed highly efficient mechanisms of cell communication to integrate and coordinate the function and proliferation of individual cell types. Gastrointestinal peptides, including gastrin and CCK (Cholecystokinin), are a structurally diverse group of molecular messengers that function in a rich network of information exchange systems throughout the organism. Gastrin, produced by G-Cells in the gastric antrum, has been identified as the circulating hormone responsible for stimulation of acid secretion from the parietal cell. Gastrin also acts as a potent cell-growth factor that has been implicated in a variety of normal and abnormal biological processes including maintenance of the gastric mucosa, proliferation of ECL (Enterochromaffin-like Cells), and neoplastic transformation. The binding of gastrin or CCK to their common cognate [...]

References:

1.Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant.
Olszewska-Pazdrak B, Townsend CM Jr, Hellmich MR.
J Biol Chem. 2004 Sep 24; 279(39):40400-4. Epub 2004 Jul 29.
2.Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways.
Noble PJ, Wilde G, White MR, Pennington SR, Dockray GJ, Varro A.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan; 284(1):G75-84.
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