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CCKBR-Gastrin Stimulated Signaling

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Multicellular organisms have developed highly efficient mechanisms of cell communication to integrate and coordinate the function and proliferation of individual cell types. Gastrointestinal peptides, including gastrin and CCK (Cholecystokinin), are a structurally diverse group of molecular messengers that function in a rich network of information exchange systems throughout the organism. Gastrin, produced by G-Cells in the gastric antrum, has been identified as the circulating hormone responsible for stimulation of acid secretion from the parietal cell. Gastrin also acts as a potent cell-growth factor that has been implicated in a variety of normal and abnormal biological processes including maintenance of the gastric mucosa, proliferation of ECL (Enterochromaffin-like Cells), and neoplastic transformation. The binding of gastrin or CCK to their common cognate [...]


1.Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant.
Olszewska-Pazdrak B, Townsend CM Jr, Hellmich MR.
J Biol Chem. 2004 Sep 24; 279(39):40400-4. Epub 2004 Jul 29.
2.Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways.
Noble PJ, Wilde G, White MR, Pennington SR, Dockray GJ, Varro A.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan; 284(1):G75-84.
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