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Description |
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CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily. It regulates leukocyte chemotaxis in inflammation and serves as a coreceptor for M-tropic (Macrophage tropic) HIV (Human Immunodeficiency Virus) entry. It serves as a functional receptor for various inflammatory CC-chemokines, including MIP1Alpha (Macrophage Inflammatory Protein-1-Alpha), MIP1Beta (Macrophage Inflammatory Protein-1-Beta), and RANTES (Regulated on Activation Normal T-Expressed and Secreted protein) and is the main coreceptor for M-tropic HIV1 strains. CCR5 is expressed in lymphoid organs such as thymus and spleen, as well as in peripheral blood leukocytes, including macrophages and T-Cells. The extracellular loops and amino-terminal domain of CCR5 are critical for binding of ligands, whereas the transmembrane carboxy-terminal helix bundle is involved in [...] |
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