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CCR5 Pathway in Macrophages

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CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily. It regulates leukocyte chemotaxis in inflammation and serves as a coreceptor for M-tropic (Macrophage tropic) HIV (Human Immunodeficiency Virus) entry. It serves as a functional receptor for various inflammatory CC-chemokines, including MIP1Alpha (Macrophage Inflammatory Protein-1-Alpha), MIP1Beta (Macrophage Inflammatory Protein-1-Beta), and RANTES (Regulated on Activation Normal T-Expressed and Secreted protein) and is the main coreceptor for M-tropic HIV1 strains. CCR5 is expressed in lymphoid organs such as thymus and spleen, as well as in peripheral blood leukocytes, including macrophages and T-Cells. The extracellular loops and amino-terminal domain of CCR5 are critical for binding of ligands, whereas the transmembrane carboxy-terminal helix bundle is involved in [...]


1.The strength of the chemotactic response to a CCR5 binding chemokine is determined by the level of cell surface CCR5 density.
Desmetz C, Lin YL, Mettling C, Portal├Ęs P, Rabesandratana H, Clot J, Corbeau P.
Immunology. 2006 Dec;119(4):551-61.
2.CCR5: From Natural Resistance to a New Anti-HIV Strategy.
Lopalco L.
Viruses. 2010 Feb;2(2):574-600.
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