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Description |
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Dynamic rearrangements of the cytoskeleton and cell adhesion are required for various cellular processes, such as shape changes, migration, and cytokinesis. These temporal and spatial reorganizations of cell structure and cell contacts can be stimulated by extracellular signals, including Growth Factors, Hormones, Integrins, G-proteins and other biologically active substances. To achieve strong adhesion to their neighbors and sustain stress and tension, epithelial cells develop many different specialized adhesive structures. Breakdown of these structures occurs during tumor progression with the development of a fibroblastic morphology characteristic of metastatic cells. Adhesion receptors of the Cadherin family have been implicated in these cellular processes, which play an important role in the development and maintenance of the differentiated epithelial phenotype during organogenesis and adult [...] |
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