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CDC42 Signaling in S. cerevisiae

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The S. cerevisiae (Saccharomyces cerevisiae) CDC42 (Cell Division Control Protein-42), a member of the Rho/Rac subfamily of Ras-Like GTPases (GTP-Binding Proteins) and Ras superfamily of low molecular-weight GTPases, is essential for the control of cell polarity during the yeast cell cycle. CDC42 occurs in both soluble and particulate pools, and neither its abundance nor its distribution varied through the cell cycle. In S. cerevisiae, CDC42 is localized to the bud site early in the cell cycle and this localization is critical for the selection of the proper site for Bud Emergence and for Polarized Cell Growth. It plays an important role in multiple Actin-dependent morphogenetic events such as Bud Emergence, Mating-Projection Formation and Pseudohyphal Growth. CDC42 transduces signals to the [...]


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