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CDC42-Actin Interactions in S. cerevisiae

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Actin cortical patches are one of the major cytoskeletal structures in yeast and are essential for normal Endocytosis, Cell Growth and Morphology. Actin cortical patches are associated with invaginations of the plasma membrane and occur in polarized clusters at regions of cell growth in budding cells (Ref.1). Patch Assembly probably begins with the association of assembly factors recruited to the plasma membrane by CDC42 (Cell Division Control Protein-42) and its associated proteins and is then followed by nucleation of Actin filaments and Actin-dependent association of proteins regulating filament assembly and stability. Prior to bud emergence in S. cerevisiae (Saccharomyces cerevisiae), cells polarize the Actin cytoskeleton toward the future bud site and assemble a Septin ring at that site. Reorganization of [...]


1.Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.
Gladfelter AS, Bose I, Zyla TR, Bardes ES, Lew DJ.
J. Cell Biol. 2002 Jan 21;156(2):315-26.
2.A protein interaction map for cell polarity development.
Drees BL, Sundin B, Brazeau E, Caviston JP, Chen GC, Guo W, Kozminski KG, Lau MW, Moskow JJ, Tong A, Schenkman LR, McKenzie A 3rd, Brennwald P, Longtine M, Bi E, Chan C, Novick P, Boone C, Pringle JR, Davis TN, Fields S, Drubin DG.
J. Cell Biol. 2001 Aug 6;154(3):549-71.
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