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CDC42-Rho Interactions in S. cerevisiae

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Cell Polarity is an essential characteristic of virtually every cell type. The budding yeast S. cerevisiae (Saccharomyces cerevisiae) has been critical for elucidation of proteins and mechanisms that underlie Cell Polarity development. Polarized Growth is mediated by a series of steps involving cortical landmarks, Rho GTPases and a polarized Actin cytoskeleton. Actin cortical patches are essential for normal Endocytosis and secretion is targeted to the bud or mating projection, allowing selective growth in that area. Patches are associated with invaginations of the plasma membrane and occur in polarized clusters at regions of cell growth in budding cells. One of the crucial Rho type GTPases is CDC42 (Cell Division Control Protein-42) which facilitates decisive event for the establishment and maintenance of [...]


1.Rho family GTPases and dendrite plasticity.
Negishi M, Katoh H.
Neuroscientist. 2005 Jun;11(3):187-91.
2.Rac1/Cdc42 and RhoA GTPases Antagonistically Regulate Chondrocyte Proliferation, Hypertrophy, and Apoptosis.
Wang G, Beier F.
J. Bone Miner. Res. 2005 Jun;20(6):1022-31.
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