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CDK5 Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


CDKs (Cyclin-dependent kinases) are a group of serine/threonine protein kinases activated by binding to a regulatory subunit cyclin. These kinases are key regulators of the eukaryotic cell cycle progression. CDK5 (also known as Neuronal CDC2-Like Kinase, NCLK) is a unique member of the CDK family, that does not act as a checkpoint kinase to regulate cell cycle progression, but acts as a regulatory kinase involved in other post-mitotic processes such as neuronal activity, neuronal migration during development and neurite outgrowth. Although the CDK5 protein is expressed at basal levels in most mammalian tissues, CDK5 activity is also seen in brain and developing muscle, as these are the only tissues that express CDK5 activators. Activation of CDK5 requires its association with [...]


1.Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.
Wang CX, Song JH, Song DK, Yong VW, Shuaib A, Hao C.
Cell Death Differ. 2005 Nov 4
2.Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.
O'Hare MJ, Kushwaha N, Zhang Y, Aleyasin H, Callaghan SM, Slack RS, Albert PR, Vincent I, Park DS.
J Neurosci. 2005 Sep 28; 25(39):8954-66.
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