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CMV and MAPK Pathways

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Signal transduction is a common process used by an extensive array of biological ligands to modulate various host cell processes such as growth, differentiation, and proliferation. Cells respond to CMV Cytomegalovirus) by invoking a cascade of biological and physiological responses resulting in signal transduction and regulation of cellular gene expression, including induction of genes in the IFN (Interferons)-responsive family (Ref.1). CMV is a herpes virus that infects most cell types and establishes latency in leukocytes. A CMV infection is normally subclinical but can be fatal in immunocompromised individuals or if the infection is acquired in utero.

One of the major components of the CMV virion is the Glycoprotein GB, and a significant proportion of the virus-host interactions are mediated through GB. [...]


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