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Description |
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CNTF (Ciliary Neurotrophic Factor) is a protein expressed in glial cells, which
stimulates gene expression and cell survival and differentiation in a variety of
neuronal cell populations and acts as a lesion factor involved in the prevention
of nerve degeneration after injury. It is a member of the GP130 (130-kDa
Glycoprotein) cytokine family along with structurally related hemato- and
neuropoietic cytokines IL-6
(Interleukin-6), IL-11
(Interleukin-11), LIF
(Leukemia Inhibitory Factor), OSM
(Oncostatin M), CT-1 (Cardiotrophin-1), Leptin and CLC
(Cardiotrophin-Like Cytokine). The actions of CNTF
are mediated, in part by CNTFR-Alpha (CNTF-specific Receptor). Upon
translation, the C-terminus of CNTFR-Alpha is cleaved. Mature CNTFR-Alpha has no
transmembrane or cytosolic domains and is found on the outer surface of the cell
membrane where it [...] |
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References:
1. CNTF, a pleiotropic cytokine: emphasis on its myotrophic role.Vergara C, Ramirez B.Brain Res Brain Res Rev. 2004 Dec; 47(1-3):161-73.2. Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro.He W, Gong K, Zhu G, Smith DK, Ip NYFEBS Lett. 2002 Mar 13; 514(2-3):214-8.
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