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CREB Pathway

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The process of consolidating a new memory and the dynamic complexity of information processing within neuronal networks is greatly increased by activity-dependent changes in gene expression within individual neurons. A leading paradigm of such regulation is the activation of the nuclear transcription factor CREB (cAMP Responsive Element Binding Protein), and its family members the ATF (Activating Transcription Factor) and CREM (cAMP Response Element Modulator), which belong to bZIP (basic/leucine zipper) class of transcription factors that functions in vivo to regulate the proliferation of pituitary cells and thymocytes. Proteins belonging to this class are characterized by the ability to bind to the consensus sequence TGACGTCA (Ref.1, 2 & 3) and contain a leucine zipper responsible for DNA binding (basic region) and for dimerization (leucine zipper [...]


1.CREB, synapses and memory disorders: past progress and future challenges.
Josselyn SA, Nguyen PV.
Curr Drug Targets CNS Neurol Disord. 2005 Oct; 4(5):481-97
2.The many faces of CREB.
Carlezon WA Jr, Duman RS, Nestler EJ.
Trends Neurosci. 2005 Aug; 28(8):436-45.
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