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CRHR Pathway

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CRH (Corticotropin-Releasing Hormone) and related peptides play a major role in coordinating the behavioral, endocrine, cardiovascular, autonomic and immune mechanisms that allow mammals to adapt under both basal and stressful conditions. Their actions are mediated through activation of two types of GPCRs (G-Protein-Coupled Receptors): CRHR1 (CRH Receptor-1) and CRHR2 (CRH Receptor-2) encoded by separate genes (Ref.1). CRH and CRH-related peptides and their receptors are widely distributed in the central nervous system, and in a variety of peripheral tissues, including the immune, cardiovascular and reproductive systems, adrenals, lungs, liver, stomach, pancreas, small intestine, skin tissues, and also in some types of human tumors. The ubiquitous distribution of CRH-related peptides and CRHRs, capable of activating diverse signaling mechanisms in different tissues, gives [...]


1.Corticotropin-releasing hormone receptors.
Hillhouse EW, Randeva H, Ladds G, Grammatopoulos D.
Biochem Soc Trans. 2002 Aug;30(4):428-32. Review.
2.Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists.
Grammatopoulos DK, Chrousos GP.
Trends Endocrinol Metab. 2002 Dec;13(10):436-44. Review.
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