ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

CRHR Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

CRH (Corticotropin-Releasing Hormone) and related peptides play a major role in coordinating the behavioral, endocrine, cardiovascular, autonomic and immune mechanisms that allow mammals to adapt under both basal and stressful conditions. Their actions are mediated through activation of two types of GPCRs (G-Protein-Coupled Receptors): CRHR1 (CRH Receptor-1) and CRHR2 (CRH Receptor-2) encoded by separate genes (Ref.1). CRH and CRH-related peptides and their receptors are widely distributed in the central nervous system, and in a variety of peripheral tissues, including the immune, cardiovascular and reproductive systems, adrenals, lungs, liver, stomach, pancreas, small intestine, skin tissues, and also in some types of human tumors. The ubiquitous distribution of CRH-related peptides and CRHRs, capable of activating diverse signaling mechanisms in different tissues, gives [...]

References:

1.Corticotropin-releasing hormone receptors.
Hillhouse EW, Randeva H, Ladds G, Grammatopoulos D.
Biochem Soc Trans. 2002 Aug;30(4):428-32. Review.
2.Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists.
Grammatopoulos DK, Chrousos GP.
Trends Endocrinol Metab. 2002 Dec;13(10):436-44. Review.
You can get all the details on this pathway through subscription