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CTLA4 Signaling

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Description

The T-Cell compartment of adaptive immunity provides vertebrates with the potential to survey for and respond specifically to an incredible diversity of antigens. In the periphery, one important level of regulation is the action of costimulatory signals in concert with TCR (T-Cell antigen Receptor) signals to promote full T-Cell activation (Ref.1). Stimulation of TCR is triggered by MHC (Major Histocompatibility Complex) molecules on Antigen Presenting Cells that present antigen peptides to TCR complexes and induce a series of intracellular signaling cascades which regulate T-Cell development, homeostasis, activation, acquisition of effector’s functions and apoptosis. All these functions are regulated through the action of various costimulatory receptors. Costimulation involves an integration of activating signals and inhibitory signals from CD28 and CTLA4 (Cytotoxic [...]

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