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CXCR4 Pathway

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The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF1) also known as CXCL12. Classically, two alternatively spliced isoforms of SDF have been identified. SDF1Alpha is an 89 amino acid protein that is the predominantly expressed form of SDF1 while SDF1Beta contains a four amino acid extension at the carboxyl terminus. Recently, an additional four splice variants that contain 30 (SDF1Gamma), 31 (SDF1Delta), 1 (SDF1Epsilon), and 51 (SDF1phi) amino acid extensions at the carboxyl terminus compared to SDF1Alpha have been identified (Ref.1).

CXCL12 is the sole ligand for the chemokine receptor CXCR4.This receptor has been described as undergoing dimerization after binding to CXCL12 or alternately in its unbound configuration. [...]


1.Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration.
Chen D, Xia Y, Zuo K, Wang Y, Zhang S, Kuang D, Duan Y, Zhao X, Wang G.
Sci Rep. 2015 Nov 18;5:16813. doi: 10.1038/srep16813.
2.Phospholipase C-β in immune cells.
Kawakami T, Xiao W.
Adv Biol Regul. 2013 Sep;53(3):249-57. doi: 10.1016/j.jbior.2013.08.001. Epub 2013 Aug 14. Review.
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