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CXCR4 Pathway

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CXCR4 (Chemokine (C-X-C motif) Receptor-4) (CD184) is a GPCR (G Protein-Coupled Receptor) with selectivity for a single CXC-motif chemokine, called SDF1 (Stromal Cell-Derived Factor-1). The chemokine receptor CXCR4 is broadly expressed in cells of both the immune and the central nervous systems and can mediate migration of resting leukocytes and haematopoietic progenitors in response to its ligand, SDF1. SDF1 exists in 2 structural variants (SDF1a and SDF1b) that differ by 4 additional amino acids in the carboxyl-terminus of the b-form but show identical receptor binding and activity profiles. It is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. Ortholog CXCR4 cDNAs are described in numerous species, including monkeys, rat, mice, cat, cow and fish. The [...]


1.Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.
Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, Hoxie JA, Peiper SC, Brass LF, Doms RW.
J Virol. 1999 Apr;73(4):2752-61.
2.Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication.
Martinez MA, Gutierrez A, Armand-Ugon M, Blanco J, Parera M, Gomez J, Clotet B, Este JA.
AIDS. 2002 Dec 6;16(18):2385-90.
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