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CXCR4 Pathway

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Description

The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF-1) also known as CXCL12. Classically, two alternatively spliced isoforms of SDF have been identified. SDF-1Alpha is an 89 amino acid protein that is the predominantly expressed form of SDF-1 while SDF-1Beta contains a four amino acid extension at the carboxyl terminus. Recently, an additional four splice variants that contain 30 (SDF-1Gamma), 31 (SDF-1Delta), 1 (SDF-1Epsilon), and 51 (SDF-1phi) amino acid extensions at the carboxyl terminus compared to SDF-1Alpha have been identified (Ref.1).

CXCL12 is the sole ligand for the chemokine receptor CXCR4.This receptor has [...]

References:

1.Regulation of CXCR4 signaling.
Busillo JM, Benovic JL.
Biochim Biophys Acta. 2007 Apr;1768(4):952-63. Epub 2006 Nov 10. Review.
2.Translating an Antagonist of Chemokine Receptor CXCR4: from bench to bedside.
Wong D, Korz W.
Clin Cancer Res. 2008 Dec 15;14(24):7975-80. doi: 10.1158/1078-0432.CCR-07-4846. Review.
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