ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Calpain Protease Regulates Cellular Mechanics

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Metastatic tumor progression, the process by which tumor cells disseminate from their primary site of development, is dependent upon the disruption of both cell-cell and cell-matrix adhesions. These in turn are governed by the multiprotein complexes of Cadherin-dependent adheren junctions and integrin-linked FA (Focal Adhesion) attachment sites. Disruption of these complexes leads to enhanced cell motility and invasion of the surrounding tissue matrix. Calpain-mediated proteolytic degradation of the Cadherin and FA complexes represent a mechanism for disassembly of these complexes (Ref.1).

Calpains are a highly conserved family of intracellular, non-lysosomal, calcium-dependent cysteine proteinases with numerous isoforms in organisms ranging from mammals to Drosophila melanogaster and Caenorhabditis elegans and with homologs in yeast and bacteria. They function in Ca2+ signaling by [...]

References:

1.Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.
Carragher NO, Fincham VJ, Riley D, Frame MC.
J Biol Chem. 2001 Feb 9; 276(6): 4270-5.
2.A Ca (2+) switch aligns the active site of calpain.
Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL.
Cell. 2002 Mar 8; 108(5): 649-60.
You can get all the details on this pathway through subscription