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Cancer Recognition

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Description

Cancer immunotherapy attempts to exploit the exquisite power and specificity of the immune system for the treatment of malignancy. Although cancer cells are less immunogenic than pathogens, the immune system is clearly capable of recognizing and eliminating tumour cells. However, tumors frequently interfere with the development and function of immune responses. Thus, the challenge for immunotherapy is to use advances in cellular and molecular immunology to develop strategies that effectively and safely augment antitumour responses. By contrast, the immune system has evolved strategies, largely in response to infections, to efficiently search for and specifically destroy diseased targets. [...]

References:

1.Cancer immunotherapy: a treatment for the masses.
Blattman JN, Greenberg PD
Science. 2004 Jul 9; 305(5681):200-5.
2.Cancer immunoediting: from immunosurveillance to tumor escape.
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD.
Nat Immunol. 2002 Nov;3(11):991-8.
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