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Cancer-Immunoediting

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Description

As research into tumour immunology continues at an incredible pace, a considerable amount of work is aimed at exploring the mechanisms that underlie the immunological recognition and elimination of cancer and the downstream consequences of these processes. The capacity of the immune system for recognition is not limited solely to the classic models of self versus pathogen or self versus non-self but encompasses the more-subtle differences that exist between self and transformed self. This conclusion provides the argument for reconsidering the largely discarded hypothesis of cancer immunosurveillance. Immune system attempts to constrain tumour growth, but some times tumour cells might escape or attenuate this immune pressure, similar to the way in which these cells evade classic mechanisms of tumour suppression. [...]

References:

1.Interferons, immunity and cancer immunoediting.
Dunn GP, Koebel CM, Schreiber RD.
Nat Rev Immunol. 2006 Nov;6(11):836-48.
2.Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.
Smyth MJ, Dunn GP, Schreiber RD.
Adv Immunol. 2006;90:1-50.
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