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Cardiolipin Synthesis in S. cerevisiae

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CL (Cardiolipin/Diphosphatidylglycerol) is a unique Phospholipid carrying four acyl groups and two negative charges. Chemically it is known as 1,3-bis (1 ,2 -diacyl-3 -phosphoryl-sn-glycerol)-sn-glycerol). CL is ubiquitous in eukaryotes and is required for activity of several mitochondrial enzymes and protein import. After the conversion of PA (Phosphatidate/Phosphatidic Acid) plus CTP (Cytidine Triphosphate) to CDP-DAG (Cytidine Diphosphate-Diacylglycerol) and pyrophosphate by CDS1 (CDP-DAG Synthase), CL biosynthesis in eukaryotes occurs in a three-step process in the mitochondrial inner membrane (Ref.1). First, PGS1/PGP Synthase (Phosphatidylglycerophosphate Synthase/CDP-Diacylglycerol-Glycerol-3-Phosphate 3-Phosphatidyltransferase) catalyzes the formation of PGP (Phosphatidylglycerophosphate) from CDP-DAG. In the second step, PGP is dephosphorylated to PG (Phosphatidylglycerol) by PGP Phosphatase. Lastly, CRD1 (Cardiolipin Synthetase) catalyzes a phosphatidyl transfer from CDP-DAG to PG, an irreversible reaction that involves cleavage of [...]


1.Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis.
Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W.
J. Biol. Chem. 2001 Oct 12;276(41):38061-7.
2.Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.
Greenberg ML, Lopes JM.
Microbiol. Rev. 1996 Mar;60(1):1-20.
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