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Catabolic Pathway for Asparagine and Aspartate

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Catabolism of Asn (Asparagine) and Asp (Aspartate or L-Aspartate or Aspartic Acid) occurs through a direct pathway consisting of amino acids with four carbon atoms, where these two molecules are catabolized into OAA (Oxaloacetate). Asn is one of the 20 most common natural amino acids on earth. It is the Beta-amido derivative of Asp (Ref.1). Asn is a non-essential amino acid, which plays an important role in the biosynthesis of glycoproteins and is also essential to the synthesis of a large number of other proteins. Asp is also a non-essential amino acid commonly occurring in the L-form. It acts as a neurotransmitter and naturally occurs in all life forms. Asp form salts with cations such as magnesium, potassium, calcium and [...]


1.Aspartate aminotransferase isoenzymes.
Panteghini, M.
Clin. Biochem. 1990 Aug;23(4):311-9.
2.Cytosolic aspartate aminotransferase gene is a member of the glucose-regulated protein gene family in adipocytes.
Plee-Gautier E, Grimal H, Aggerbeck M, Barouki R, Forest C.
Biochem. J. 1998 Jan 1;329 ( Pt 1):37-40.
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