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Cell Cycle Control of Chromosomal Replication

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Description

The stable propagation of genetic information requires that the entire genome of an organism be faithfully replicated only once in each cell cycle. In eukaryotes, this replication is initiated at hundreds to thousands of replication origins distributed over the genome, each of which must be prohibited from re-initiating DNA replication within every cell cycle (Ref.1). Initiation of DNA replication occurs by a two-step process. In the first step initiation proteins are assembled onto the replication origin in a step-wise fashion to yield an initiation complex. In the second step the initiation complex is activated by protein kinases, resulting in the establishment of replication forks. This process is tightly regulated such that initiation at a given replication origin occurs only once [...]

References:

1.Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Nguyen VQ, Co C, Li JJ.
Nature. 2001 Jun 28; 411(6841): 1068-73.
2.Putting it all together: building a prereplicative complex.
Newlon CS.
Cell. 1997 Dec 12; 91(6): 717-20. Review. No abstract available.
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