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Cellular Apoptosis Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and function of an organism. In this process, cells that are no longer needed or that will be detrimental to an organism or tissue are disposed of in a neat and orderly manner; this prevents the development of an inflammatory response, which is often associated with Necrotic cell death. There are at least two broad pathways that lead to Apoptosis, an "Extrinsic" and an "Intrinsic" Pathway. In both pathways, signaling results in the activation of a family of Cys (Cysteine) Proteases, named Caspases that act in a proteolytic cascade [...]

References:

1.Programmed cell death: Apoptosis meets necrosis.
Peter ME.
Nature. 2011 Mar 17;471(7338):310-2.
2.Harnessing tumor necrosis factor receptors to enhance antitumor activities of drugs.
Muntané J.
Chem Res Toxicol. 2011 Oct 17;24(10):1610-6. Epub 2011 Jul 21.
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