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Cellular Effects of Sildenafil

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Erectile Dysfunction commonly known as ED or Impotence, affects a large segment of the male population that results in impaired relaxation of the smooth muscle cells in the corpus cavernosum and in the penile arteries. It is an age-related problem that is increasingly common in men aged over 40 years. In the past, ED was often assumed to be either a psychological problem or a normal part of the ageing process, to be tolerated with other signs of aging. However, ED is now known to be primarily organic resulting from vascular, hormonal or neurological complications. The corpus cavernosum (cavernous space) contains sinusoids that are surrounded by trabecular smooth muscle (Ref.1). Upon sexual stimulation, the increase in parasympathetic activity results in [...]


1.Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Ghofrani HA, Osterloh IH, Grimminger F.
Nat. Rev. Drug Discov. 2006 Aug;5(8):689-702.
2.Sildenafil: from the bench to the bedside.
Michelakis E, Tymchak W, Archer S.
CMAJ. 2000 Oct 31;163(9):1171-5.
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