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ChREBP Regulation in Rattus norvegicus

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The liver is the major organ responsible for the conversion of excess dietary carbohydrate into triglycerides. Ins (Insulin) and Glucagon (a pancreatic hormone) play critical roles in homeostatsis of Glucose and triglycerides in humans as well as in R. norvegicus (Rattus norvegicus). Glucose serves as a signal independent of hormones in activation of more than 15 enzyme genes in the lipogenic pathways. However, the mechanism by which Glucose generates signal to induce these gene is not known (Ref.1). Ingestion of a high carbohydrate diet leads to the activation of several regulatory enzymes of Glycolysis and Lipogenesis, including the PKLR (Pyruvate Kinase, Liver and RBC), also known as LPK (L-Type Pyruvate Kinase). The lipogenic genes contain ChREs (Carbohydrate Responsive Elements) within their promoters that mediate [...]


1.Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage.
Uyeda K, Yamashita H, Kawaguchi T.
Biochem. Pharmacol. 2002 Jun 15;63(12):2075-80.
2.Modulation of carbohydrate response element-binding protein ChREBP gene expression in 3T3-L1 adipocyte and rat adipose tissue.
He Z, Jiang T, Wang Z, Levi M, Li J.
Am. J. Physiol. Endocrinol. Metab. 2004 Apr 20
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