This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
|
|
Description |
|
Cells activate checkpoint pathways in response to DNA damage or a block to
replication, that prevent cell cycle progression by inhibiting the basic cell
cycle machinery until the problem is fixed. Various forms of DNA damage and
various treatments that block replication trigger these checkpoints. Recent work
on the mechanisms of DNA damage and replication cell cycle checkpoints has
revealed great similarity between the checkpoint pathways of organisms as
diverse as yeasts, flies, humans and mouse. However, there are differences in
the ways these organisms regulate their cell cycles. In fission yeast,
checkpoint responds to DNA damage induced by IR (Ionizing Radiation) and UV
light, as well as to DNA replication inhibitors. In humans and mouse, Chk
(Checkpoint Kinase) is [...] |
|
|
References:
|
|
|
|
|