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Checkpoint Comparative Pathways

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Cells activate checkpoint pathways in response to DNA damage or a block to replication, that prevent cell cycle progression by inhibiting the basic cell cycle machinery until the problem is fixed. Various forms of DNA damage and various treatments that block replication trigger these checkpoints. Recent work on the mechanisms of DNA damage and replication cell cycle checkpoints has revealed great similarity between the checkpoint pathways of organisms as diverse as yeasts, flies, humans and mouse. However, there are differences in the ways these organisms regulate their cell cycles. In fission yeast, checkpoint responds to DNA damage induced by IR (Ionizing Radiation) and UV light, as well as to DNA replication inhibitors. In humans and mouse, Chk (Checkpoint Kinase) is [...]


1.Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
Zhao H, Watkins JL, Piwnica-Worms H
Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23): 14795-800. Epub 2002 Oct 24
2.ATM-related genes: what do they tell us about functions of the human gene?
Zakian VA
Cell. 1995 Sep 8; 82(5): 685-7.
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