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Checkpoint Signaling in Yeast

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The maintenance of genomic integrity is important for the survival of eukaryotic cells. Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. Various forms of DNA damage and various treatments that block replication trigger these checkpoints. Checkpoint pathways and proteins are evolutionarily conserved from yeast to man, underlining their importance in maintaining genomic integrity. In the fission yeast, Schizosaccharomyces pombe, several checkpoint pathways monitor the status of the DNA and arrest the cell cycle in response to DNA damage or inhibition of DNA replication induced by Ionizing Radiation and UV light (Ref.1). The checkpoint Rad proteins, Rad1, Rad3, Rad4, Rad9, Rad17, Rad26 and Hus1, are required for damage sensing and processing [...]


1.Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.
Zhao H, Watkins JL, Piwnica-Worms H.
Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23): 14795-800. Epub 2002 Oct 24.
2.The G2-phase DNA-damage checkpoint.
O'Connell MJ, Walworth NC, Carr AM.
Trends Cell Biol. 2000 Jul; 10(7): 296-303. Review.
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