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Chemokine Signaling

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Description

Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. Initially chemokines were divided into groups based on having chemotactic or homeostatic function, but several dual-function chemokines have since been described. To date, 44 chemokines and 23 chemokine receptors have been identified in the human genome. It is the expression of particular chemokines, receptors, and adhesion molecules that contribute to the selective migration and tissue specificity of leukocytes. Chemokines can be subdivided into four families based on the positioning of the N-terminal cysteine residues (Ref.1 & 2).

Chemokines mediate their effects through interactions with seven-transmembrane-spanning glyco-protein receptors coupled to a G-protein signaling pathway. [...]

References:

1.Chemokine signaling in development and disease.
Wang J, Knaut H.
Development. 2014 Nov;141(22):4199-205. doi: 10.1242/dev.101071. Review.
2.Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Turner MD, Nedjai B, Hurst T, Pennington DJ.
Biochim Biophys Acta. 2014 Nov;1843(11):2563-2582. doi: 10.1016/j.bbamcr.2014.05.014. Epub 2014 Jun 2. Review.
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