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Chemokine Signaling

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Chemokines, or chemotactic cytokines, are a large family of small (6–14 kDa), structurally related proteins that mediate a wide range of biological activities. As a part of normal immune system functions, chemokines are a critical component of basal leukocyte trafficking essential for immune system architecture and development, and immune surveillance. Chemokines also participate in the growth, differentiation, and activation of leukocytes as well as stimulate various effector functions of these cells, such as integrin activation, chemotaxis, superoxide radical production and granule enzyme release. Four classes of chemokines have been defined by the arrangement of the conserved cysteine (C) residues of the mature proteins: the CXC chemokines the CC chemokines in which the first two conserved cysteines residues are adjacent; the [...]


1.The chemokine family. Potential therapeutic targets from allergy to HIV infection.
Eur J Dermatol. 1998 Apr-May;8(3):147-57.
2.Chemokine receptors and their role in inflammation and infectious diseases.
Murdoch C, Finn A.
Blood. 2000 May 15;95(10):3032-43.
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