ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Chks in Checkpoint Regulation

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

In the presence of DNA damage or incomplete DNA replication, eukaryotic cells activate cell cycle checkpoints that temporarily halt the cell cycle to permit DNA repair or completion of DNA replication to take place. In the presence of extensive damage or absence of timely repair, these checkpoint-signaling pathways may also trigger a pathway that effects programmed cell death or apoptosis (Ref.1). DNA damage-activated cell cycle checkpoints are regulated in part by the phosphoinositide kinase family of checkpoint components, including the yeast Rad3 in Schizosaccharomyces pombe, Mec1/Tel1 in Saccharomyces cerevisiae, mammalian ATM (Ataxia Telangiectasia-Mutated), ATR (ATM/Rad3-related), MEI-41 in Drosophila, and X-ATM and X-ATR in Xenopus. These checkpoint kinases regulate the activities of two downstream effector serine/threonine kinases, CDS1 and Chk1 (Csk [...]

References:

You can get all the details on this pathway through subscription