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Cholera Infection

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Description

Cholera is one of the most severe diarrheal diseases that affect humans and is responsible for significant morbidity and mortality especially among children in developing countries. It is characterized by numerous, voluminous watery stools, often accompanied by vomiting, and resulting in hypovolemic shock and acidosis. It is caused by certain members of the species Vibrio cholerae which can also cause mild or inapparent infections. Other members of the species may occasionally cause isolated outbreaks of milder Diarrhea whereas others the vast majorities are free-living and not associated with disease. The causative agent of Cholera, Vibrio cholerae, is a Gram-negative highly motile bacterium with a single polar flagellum that inhabits rivers, estuaries or other aquatic environments. Cholera is a water-borne disease [...]

References:

1.A critical new pathway for toxin secretion?
Yahr TL.
N Engl J Med. 2006 Sep 14;355(11):1171-2.
2.Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review).
De Haan L, Hirst TR.
Mol Membr Biol. 2004 Mar-Apr;21(2):77-92.
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