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Description |
Simple eukaryotes such as yeasts and molds encode multiple PAKs (p21-Activated
Kinases) that, like their orthologs in other systems, act downstream of
Rho-family GTPases to regulate cytoskeletal structure and gene transcription.
All PAKs contain an N-terminal PBD (p21 GTPase-Binding-Domain), which confers
binding to small GTPases such as CDC42 (Cell Division Cycle-42) or Rac, and a
C-terminal protein kinase domain (Ref.1). Saccharomyces cerevisiae
cells contain three members of this family, Ste20, Cla4, and Skm1, each of which
performs a distinct set of cellular roles.
S. cerevisiae Cla4
contains a CDC42-binding domain, a PH (Pleckstrin Homology) domain, and a
serine/threonine kinase domain and is required for viability in the absence of
the G1 cyclins Cln1 and Cln2. Like Ste20, Cla4 is part of [...] |
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References:
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