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Cleavage and Polyadenylation of Pre-mRNA

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Description

During the course of transcription, the initial RNA product synthesized by RNA-PolII (RNA Polymerase-II), called a Primary transcript undergoes several processing steps including Capping, Splicing and Polyadenylation, before a functional mRNA (messenger RNA) is produced. RNA Polymerase initiates transcription at the first nucleotide of the first exon of a gene. Shortly after transcription begins, the 5 end of the nascent RNA is capped with 7-Methyl-Guanylate.Transcription by RNA polymerase-II terminates at any one of the multiple sites approx. 0.5-2kb downstream from the 3 end of the last exon in the transcript. The 3 end of a functional mRNA then is generated by endonucleolytic cleavage at a specific sequence, the Poly-A site, located at the 3 end of the final exon. A [...]

References:

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