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Colorectal Cancer Metastasis

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Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. Colorectal cancer results from the accumulation of genetic alterations. Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. Several forms of genomic instability are common in colon cancer: MSI (Microsatellite Instability), CIN (Chromosome Instability), and chromosome translocations. MSI occurs in approximately 15% of colon cancers and results from inactivation of the MMR (Mismatch Repair) system secondary to either MMR gene mutations or hypermethylation of MMR gene promoters. It promotes tumorigenesis by generating mutations in target genes that possess coding microsatellite repeats. CIN occurs in most other [...]


1.Signal Transduction Cross-talk During Colorectal Tumorigenesis.
Liu X, Lazenby AJ, Siegal GP.
Adv. Anat. Pathol. 2006 Sep;13(5):270-274.
2.Genomic instability and colorectal cancer.
Grady WM, Markowitz S.
Curr. Opin. Gastroenterol. 2000 Jan;16(1):62-67.
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