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Complement Pathway

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The C (Complement) system consists of about twenty plasma proteins that function either as enzymes or as binding proteins. In addition to these plasma proteins, the complement system includes multiple distinct cell-surface receptors that exhibit specificity for the physiological fragments of complement proteins and that occur on inflammatory cells and cells of the immune system. Activation of the complement system initiates a series of enzymatic reactions in which the proteolytic cleavage and activation of successive complement proteins leads to the covalent bonding or fixing of complement fragments to the pathogen surface. A major consequence of this is the uptake and destruction of complement coated microbes by phagocytes that bear receptors for these complement fragments (Ref.1).

Most complement proteins exist in [...]


1.Evolution of complement as an effector system in innate and adaptive immunity.
Sunyer JO, Boshra H, Lorenzo G, Parra D, Freedman B, Bosch N.
Immunol Res. 2003;27(2-3):549-64.
2.Complement: structure, functions, evolution, and viral molecular mimicry.
Mastellos D, Morikis D, Isaacs SN, Holland MC, Strey CW, Lambris JD.
Immunol Res. 2003;27(2-3):367-86.
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