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D-Alanine Metabolism in B. anthracis Sterne

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Bacilli are rod-shaped, Gram-positive, sporulating, aerobes or facultative anaerobes. Bacilli exhibit an array of physiologic abilities that allow them to live in a wide range of habitats, including many extreme habitats such as desert sands, hot springs, and Arctic soils. Species in the genus Bacillus can be thermophilic, psychrophilic, acidophilic, alkaliphilic, halotolerant, or halophilic and are capable of growing at pH values, temperatures, and salt concentrations where few other organisms can survive (Ref.1, 2 & 4). Due to the metabolic diversity in the genus Bacillus, Bacilli are able to colonize a variety of habitats ranging from soil to insects, to humans. The three species of the Group-1 Bacilli, B. anthracis, B. cereus, and B. thuringiensis, are genetically very closely related. [...]


1.In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones.
Brook I, Elliott TB, Pryor HI 2nd, Sautter TE, Gnade BT, Thakar JH, Knudson GB.
Int J Antimicrob Agents. 2001 Dec; 18(6):559-62.
2.Proteomic analysis of Bacillus anthracis Sterne vegetative cells.
Francis AW, Ruggiero CE, Koppisch AT, Dong J, Song J, Brettin T, Iyer S.
Biochim Biophys Acta. 2005 May 15; 1748(2):191-200.
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