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D-Alanine Metabolism in B. halodurans

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Description

Bacillus species and other microbes with pH optima for growth higher than pH 9 are defined as alkaliphiles. A large number of alkaliphilic Bacillus strains producing useful enzymes, have been isolated from various environments. Bacillus halodurans is an alkaliphilic Bacillus species that grows optimally above pH 9.5. It is the second Bacillus species whose entire genomic sequence has been completely defined. B. halodurans is similar to B. subtilis in terms of genome size, G+C content, and physiological properties, except for its alkaliphilic phenotype (Ref.1, 2 & 3).

The cell wall of these Gram-positive bacteria is a unique biopolymer, containing both D- and L-Amino acids. Its basic structure is a carbohydrate backbone of alternating units of N-Acetyl Glucosamine and N-Acetyl Muramic Acid. [...]

References:

1.Starch hydrolysing Bacillus halodurans isolates from a Kenyan soda lake.
Hashim SO, Delgado O, Hatti-Kaul R, Mulaa FJ, Mattiasson B.
Biotechnol Lett. 2004 May; 26(10):823-8.
2.Regulation of the tryptophan biosynthetic genes in Bacillus halodurans: common elements but different strategies than those used by Bacillus subtilis.
Szigeti R, Milescu M, Gollnick P.
J Bacteriol. 2004 Feb; 186(3):818-28.
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