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D-Alanine Metabolism in B. melitensis

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Description

Brucella is a Gram-negative aerobic pathogen that is distringuished from most other pathogens because it does not have "obvious virulence factors" like capsules, fimbriae, flagella, exotoxins, exproteases, or other exoenzymes, cytolysins, resistance forms, antigenic variation, plamids, or lysogenic phages (Ref.1). Brucella sp. causes a "zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febrile illness in humans". Brucella melitensis is the cause of brucellosis in goats, cattle, sheep, pigs, dogs, marine mammals, and several wild animals. Goats are the natural hosts for B. melitensis. This bacterium is also the cause of a rarer, more severe systemic infection called neurobrucellosis. Most features related to virulence seem to [...]

References:

1.Brucella melitensis: a nasty bug with hidden credentials for virulence.
Moreno E, Moriyon I.
Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):1-3.
2.Indirect enzyme-linked immunosorbent assay for detection of Brucella melitensis-specific antibodies in goat milk.
Funk ND, Tabatabai LB, Elzer PH, Hagius SD, Martin BM, Hoffman LJ.
J Clin Microbiol. 2005 Feb; 43(2):721-5.
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