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D-Alanine Metabolism in B. suis

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Bacteria of the genus Brucella are Gram-negative facultative intracellular pathogens of various wild and domestic mammals and are able to cause brucellosis, a severe zoonotic infection affecting ruminants, pigs, dogs, rodents, and cetacean. Traditionally, three major species are distinguished by their predilections for certain animal hosts: Brucella abortus for cattle, Brucella melitensis for caprines, and Brucella suis for hogs. Whereas B. abortus is the livestock pathogen with the greatest economic impact, B. melitensis and B. suis account for most clinical cases in humans (Ref.1, 2 & 3). Human brucellosis, or Malta fever, is a serious debilitating disease that is rife in endemic areas including the Mediterranean basin and Latin America. The key aspect of Brucella virulence is its ability to [...]


1.Laboratory-based diagnosis of brucellosis--a review of the literature. Part I: Techniques for direct detection and identification of Brucella spp.
Al Dahouk S, Tomaso H, Nockler K, Neubauer H, Frangoulidis D.
Clin Lab. 2003;49(9-10):487-505. Review.
2.Oral vaccination with Brucella melitensis WR201 protects mice against intranasal challenge with virulent Brucella melitensis 16M.
Izadjoo MJ, Bhattacharjee AK, Paranavitana CM, Hadfield TL, Hoover DL.
Infect Immun. 2004 Jul;72(7):4031-9.
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