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D-Alanine Metabolism in C. crescentus

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Caulobacter crescentus is a Gram-negative non-pathogenic bacterium that grows in dilute aquatic environments. It is a member of the Alpha-subdivision of Proteobacteria. C. crescentus invariably differentiates and divides asymmetrically at each cell cycle. C. crescentus is a simple and highly manipulable single-celled model system to study cellular differentiation, asymmetric division, and their coordination with Cell Cycle progression (Ref.1 & 2). The cell wall of this bacterium is a unique biopolymer, containing both D- and L-Amino acids. The terminal peptide is D-Alanine although other amino acids are present as D-isomers and this is the only known biological molecule that contains D-Amino acids, which are responsible for the building of peptidoglycan. A key step in peptidoglycan layer assembly and deposition is the [...]


1.Identification and cell cycle control of a novel pilus system in Caulobacter crescentus.
Skerker JM, Shapiro L.
EMBO J. 2000 Jul 3; 19(13):3223-34.
2.Complete genome sequence of Caulobacter crescentus.
Nierman WC, Feldblyum TV, Laub MT, Paulsen IT, Nelson KE, Eisen JA, Heidelberg JF, Alley MR, Ohta N, Maddock JR, Potocka I, Nelson WC, Newton A, Stephens C, Phadke ND, Ely B, DeBoy RT, Dodson RJ, Durkin AS, Gwinn ML, Haft DH, Kolonay JF, Smit J, Craven MB, Khouri H, Shetty J, Berry K, Utterback T, Tran K, Wolf A, Vamathevan J, Ermolaeva M, White O, Salzberg SL, Venter JC, Shapiro L, Fraser CM.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4136-41. Epub 2001 Mar 20. Erratum in: Proc Natl Acad Sci U S A 2001 May 22; 98(11):6533. Eisen J [corrected to Eisen JA].
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