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D-Alanine Metabolism in L. innocua

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The bacterial genus Listeria is currently taxonomically subdivided into six species: L. monocytogenes, L. seeligeri, L. ivanovii, L. innocua, L. grayi, and L. welshimeri. Two of the species are pathogenic, causing the disease listeriosis. L. innocua is widespread in the environment and in food. The only phenotypic characteristic that classically distinguishes L. monocytogenes from L. innocua is hemolysis (Ref.1). As in most Gram-positive bacteria, the cell wall of L. monocytogenes is composed of a thick peptidoglycan containing two types of anionic polymers: (i) the TAs (Teichoic Acids), which are covalently linked to the peptidoglycan; and (ii) the LTAs (Lipoteichoic Acids), which are polyphosphoglycerol substituted with a D-Ala (D-Alanyl) ester or a glycosyl residue and are anchored in the membrane by [...]


1.Natural atypical Listeria innocua strains with Listeria monocytogenes pathogenicity island 1 genes.
Johnson J, Jinneman K, Stelma G, Smith BG, Lye D, Messer J, Ulaszek J, Evsen L, Gendel S, Bennett RW, Swaminathan B, Pruckler J, Steigerwalt A, Kathariou S, Yildirim S, Volokhov D, Rasooly A, Chizhikov V, Wiedmann M, Fortes E, Duvall RE, Hitchins AD.
Appl Environ Microbiol. 2004 Jul; 70(7):4256-66.
2.Analysis of the Listeria cell wall proteome by two-dimensional nanoliquid chromatography coupled to mass spectrometry.
Calvo E, Pucciarelli MG, Bierne H, Cossart P, Pablo Albar J, Garcia-Del Portillo F.
Proteomics. 2005 Feb; 5(2):433-43.
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