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D-Alanine Metabolism in L. monocytogenes F2365

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Description

Listeria monocytogenes is a Gram-positive bacterium widely spread in nature and responsible for sporadic severe infections in humans and other animal species. This pathogen is a facultative intracellular microorganism capable of invading and surviving in most host cells, including epithelial cells and macrophages (Ref.1). L. monocytogenes strain F2365 (Serotype 4b) has been isolated from Jalisco cheese outbreak in 1985 in California. As in most Gram-positive bacteria, the cell wall of L. monocytogenes is composed of a thick peptidoglycan containing two types of anionic polymers: (i) the TAs (Teichoic Acids), which are covalently linked to the peptidoglycan; and (ii) the LTAs (Lipoteichoic Acids), which are polyphosphoglycerol substituted with a D-Ala (D-Alanyl) ester or a glycosyl residue and are anchored in the [...]

References:

1.Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Thompson RJ, Bouwer HG, Portnoy DA, Frankel FR.
Infect Immun. 1998 Aug; 66(8):3552-61.
2.Interaction between the protein InlB of Listeria monocytogenes and lipoteichoic acid: a novel mechanism of protein association at the surface of gram-positive bacteria.
Jonquieres R, Bierne H, Fiedler F, Gounon P, Cossart P.
Mol Microbiol. 1999 Dec; 34(5):902-14
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