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D-Alanine Metabolism in L. monocytogenes EGD-e

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Listeria monocytogenes is a Gram-positive facultative intracellular bacterial pathogen that elicits a strong cellular immune response following infection and therefore has potential use as a vaccine vector. However, while infections by L. monocytogenes are fairly rare and can readily be controlled by a number of antibiotics, the organism can nevertheless cause meningitis and death, particularly in immunocompromised or pregnant patients (Ref.1). L. monocytogenes EGD-e (Serovar 1/2a) is a derivative of strain EGD. As in most Gram-positive bacteria, the cell wall of L. monocytogenes is composed of a thick peptidoglycan containing two types of anionic polymers: (i) the TAs (Teichoic Acids), which are covalently linked to the peptidoglycan; and (ii) the LTAs (Lipoteichoic Acids), which are polyphosphoglycerol substituted with a D-Ala [...]


1.Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.
Thompson RJ, Bouwer HG, Portnoy DA, Frankel FR.
Infect Immun. 1998 Aug; 66(8):3552-61.
2.Interaction between the protein InlB of Listeria monocytogenes and lipoteichoic acid: a novel mechanism of protein association at the surface of gram-positive bacteria.
Jonquieres R, Bierne H, Fiedler F, Gounon P, Cossart P.
Mol Microbiol. 1999 Dec; 34(5):902-14.
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