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D-Alanine Metabolism in M. capsulatus

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Methanotrophs are a unique group of Gram-negative bacteria that grow aerobically on methane and utilize methane as the sole source of carbon and energy. Methanotrophs such as Methylococcus capsulatus are responsible for the oxidation of biologically generated methane, and they are therefore of great environmental importance in reducing the amount of this greenhouse gas released to the Earth s atmosphere (Ref.1). A key step in peptidoglycan layer assembly and deposition in the cell wall of M. capsulatus is the subsequent enzymic cross-linking of one peptidoglycan strand to an adjacent one in cell wall growth. D-Alanine is a central molecule in this peptidoglycan assembly and cross-linking. The naturally occurring L-Alanine isomer is racemized to its D-form through the action of AlRs (Alanine [...]


1.Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath).
Ward N, Larsen O, Sakwa J, Bruseth L, Khouri H, Durkin AS, Dimitrov G, Jiang L, Scanlan D, Kang KH, Lewis M, Nelson KE, Methe B, Wu M, Heidelberg JF, Paulsen IT, Fouts D, Ravel J, Tettelin H, Ren Q, Read T, DeBoy RT, Seshadri R, Salzberg SL, Jensen HB, Birkeland NK, Nelson WC, Dodson RJ, Grindhaug SH, Holt I, Eidhammer I, Jonasen I, Vanaken S, Utterback T, Feldblyum TV, Fraser CM, Lillehaug JR, Eisen JA.
PLoS Biol. 2004 Oct;2(10):e303. Epub 2004 Sep 21
2.Characterization of the alanine racemases from two mycobacteria.
Strych U, Penland RL, Jimenez M, Krause KL, Benedik MJ.
FEMS Microbiol Lett. 2001 Mar 15;196(2):93-8
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