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D-Alanine Metabolism in R. solanacearum GMI1000

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Ralstonia solanacearum (previously named Pseudomonas solanacearum) is a devastating, soil-borne plant pathogen and the causal agent of bacterial wilt, one of the most important bacterial diseases worldwide. Hundreds of different plant species, including many important agricultural crops such as potato, tomato, banana, pepper, and even trees such as eucalyptus are affected by this vascular pathogen (Ref.1). It is a model system for the dissection of molecular determinants governing pathogenicity. It exhibits a strong and tissue-specific tropism within the host, specifically invading, and highly multiplying in, the xylem vessels of the roots. R. solanacearum is a Beta-Proteobacterium and thus belongs to a group of bacteria whose genomic organization is still poorly characterized. A key step in peptidoglycan layer assembly and deposition [...]


1.Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes.
Deslandes L, Olivier J, Theulieres F, Hirsch J, Feng DX, Bittner-Eddy P, Beynon J, Marco Y.
Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2404-9. Epub 2002 Feb 12.
2.Characterization of the alanine racemases from two mycobacteria.
Strych U, Penland RL, Jimenez M, Krause KL, Benedik MJ.
FEMS Microbiol Lett. 2001 Mar 15;196(2):93-8
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