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D-Alanine Metabolism in S. agalactiae 2603

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Description

Streptococcus agalactiae, or Group-B Streptococcus is a Gram-positive nonmotile bacterium and is the leading cause of bacterial sepsis, pneumoniae and meningitidis in neonates in U.S. and Europe. It usually behaves as a commensal organism that colonizes the gastrointestinal or genital tract of 25-40% of healthy women, but it can cause life-threatening invasive infection in susceptible hosts: newborn infants, pregnant women, and adults with underlying chronic illnesses (Ref.1, 2 & 4). First recognized as a pathogen in bovine mastitis, S. agalactiae (Group-B Streptococci [GBS]) is distinguished from other pathogenic streptococci by the cell wall-associated Group-B carbohydrate (Ref.3).

As is the case in other Gram-positive bacteria, the cell wall of S. agalactiae is associated with an array of proteins which can share common [...]

References:

1.Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.
Tettelin H, Masignani V, Cieslewicz MJ, Eisen JA, Peterson S, Wessels MR, Paulsen IT, Nelson KE, Margarit I, Read TD, Madoff LC, Wolf AM, Beanan MJ, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Kolonay JF, Madupu R, Lewis MR, Radune D, Fedorova NB, Scanlan D, Khouri H, Mulligan S, Carty HA, Cline RT, Van Aken SE, Gill J, Scarselli M, Mora M, Iacobini ET, Brettoni C, Galli G, Mariani M, Vegni F, Maione D, Rinaudo D, Rappuoli R, Telford JL, Kasper DL, Grandi G, Fraser CM.
Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12391-6. Epub 2002 Aug 28.
2.Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease.
Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L, Poyart C, Trieu-Cuot P, Kunst F.
Mol Microbiol. 2002 Sep; 45(6):1499-513.
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