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D-Alanine Metabolism in S. aureus MSSA476

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Description

Staphylococcus aureus are Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. S. aureus is an important nosocomial and community-acquired pathogen. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major and constantly changing clinical challenge. Two disease-causing S. aureus strains have been isolated from distinct clinical settings: a recent hospital-acquired representative of the EMRSA-16 (Epidemic Methicillin-Resistant S. aureus) clone (MRSA252), a clinically important and globally prevalent lineage; and a representative of an invasive community-acquired MSSA476 (Methicillin-Susceptible S. aureus) clone. The genome sequences of MRSA252 and MSSA476 have [...]

References:

1.Nucleotide substitution and recombination at orthologous loci in Staphylococcus aureus.
Hughes AL, Friedman R.
J Bacteriol. 2005 Apr; 187(8):2698-704.
2.Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J.
Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9786-91.
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