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D-Alanine Metabolism in S. aureus MW2

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Staphylococcus aureus are Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. S. aureus is one of the major causes of community-acquired and hospital-acquired infections. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever. S. aureus MW2 is a typical community-acquired strain of MRSA (Methicillin-Resistant S. aureus) isolated in 1998 in North Dakota (Ref.1, 2 & 7).

The staphylococcal cell wall is 50 percent peptidoglycan by weight consisting of alternating polysaccharide subunits of N-Acetylglucosamine and N-Acetylmuramic acid with 1, 4-Beta linkages. The peptidoglycan chains are cross-linked by tetrapeptide chains bound to N-Acetylmuramic acid and by a pentaglycine bridge specific for S. aureus. Peptidoglycan may [...]


1.A spectrum of changes occurs in peptidoglycan composition of glycopeptide-intermediate clinical Staphylococcus aureus isolates.
Boyle-Vavra S, Labischinski H, Ebert CC, Ehlert K, Daum RS.
Antimicrob Agents Chemother. 2001 Jan; 45(1):280-7.
2.Genome and virulence determinants of high virulence community-acquired MRSA.
Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K. Genome and virulence determinants of high virulence community-acquired MRSA.
Lancet. 2002 May 25; 359(9320):1819-27.
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