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D-Alanine Metabolism in S. aureus Mu50

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Staphylococcus aureus are facultative anaerobic Gram-positive cocci, that is a major cause of hospital acquired (nosocomial) infection of surgical wounds and infections associated with indwelling medical devices. S. aureus causes food poisoning by releasing enterotoxins into food, and toxic shock syndrome by release of superantigens into the blood stream. Over the last decade, VRSA (Vancomycin Resistant S. aureus) strains have become endemic in hospitals worldwide. The VRSA phenotype of S. aureus Mu50 is the result of changes to the cell wall structure. In comparison with MRSA strains, Mu50 and Mu50-like strains have a thickened cell wall, release more cell wall material into the culture medium and have increased rates of autolysis (Ref.1, 2 & 7).

The fine structure of the Mu50 [...]


1.A spectrum of changes occurs in peptidoglycan composition of glycopeptide-intermediate clinical Staphylococcus aureus isolates.
Boyle-Vavra S, Labischinski H, Ebert CC, Ehlert K, Daum RS.
Antimicrob Agents Chemother. 2001 Jan; 45(1):280-7.
2.Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315.
Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H.
DNA Res. 2004 Feb 29; 11(1):51-6.
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