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D-Alanine Metabolism in S. aureus N315

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Staphylococcus aureus are facultative anaerobic Gram-positive cocci, that is a major cause of hospital acquired (nosocomial) infection of surgical wounds and infections associated with indwelling medical devices. S. aureus causes food poisoning by releasing enterotoxins into food, and toxic shock syndrome by release of superantigens into the blood stream. S. aureus N315 was isolated as an MRSA (Methicillin-Resistant S. aureus) that was a major pathogen causing hospital-acquired infections in 1982 (Ref.1, 2 & 6).

The staphylococcal cell wall is 50 percent peptidoglycan by weight consisting of alternating polysaccharide subunits of N-Acetylglucosamine and N-Acetylmuramic acid with 1, 4-Beta linkages. The peptidoglycan chains are cross-linked by tetrapeptide chains bound to N-Acetylmuramic acid and by a pentaglycine bridge specific for S. aureus. Peptidoglycan may [...]


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