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D-Alanine Metabolism in S. epidermidis RP62A

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Staphylococcus epidermidis is a Gram-positive nonmotile bacterium that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. It produces numerous toxins including superantigens that cause unique disease entities and has emerged as a causative agent of infections often associated with implanted medical devices. The S. aureus and S. epidermidis genomes are syntenic throughout their lengths and share a core set of 1,681 ORF (Open Reading Frames). A 2.6-Mb genome of S.epidermidis RP62A, a methicillin-resistant biofilm isolate has recently been isolated (Ref.1 & 2).

The cell wall of S. epidermidis is 50 percent peptidoglycan by weight consisting of alternating polysaccharide subunits of N-Acetylglucosamine and N-Acetylmuramic acid with 1, 4-Beta linkages. The peptidoglycan chains are cross-linked by tetrapeptide chains bound to N-Acetylmuramic acid and [...]


1.Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain.
Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM.
J Bacteriol. 2005 Apr; 187(7):2426-38.
2.Significance of Staphylococcus epidermidis causing subclinical infection.
Mladick RA.
Plast Reconstr Surg. 2005 Apr 15; 115(5):1426-7; author reply 1427-8.
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