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D-Alanine Metabolism in S. meliloti

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Sinorhizobium meliloti (formerly Rhizobium meliloti), is a common Gram-negative soil and rhizosphere bacterium, that forms nitrogen-fixing nodules on the roots of certain genera of leguminous plants, including Medicago, Melilotus and Trigonella sp. Inside the nodules, differentiated bacteria called bacteroids fix atmospheric nitrogen (i.e. reduce N2 into NH3) to the benefit of the plant. Nodule formation and the subsequent nitrogen-fixation result from a series of interactions controlled by the exchange of molecular signals between symbiotic bacteria and host plants followed by expression of genes from both symbiotic partners. S. meliloti surface polysaccharides, including exopolysaccharides, lipopolysaccharides, capsular polysaccharides, and cyclic Beta-Glucans are crucial for successful plant infection, possibly by suppressing plant defense responses (Ref.1). A key step in peptidoglycan layer assembly and [...]


1.The composite genome of the legume symbiont Sinorhizobium meliloti.
Galibert F, Finan TM, Long SR, Puhler A, Abola P, Ampe F, Barloy-Hubler F, Barnett MJ, Becker A, Boistard P, Bothe G, Boutry M, Bowser L, Buhrmester J, Cadieu E, Capela D, Chain P, Cowie A, Davis RW, Dreano S, Federspiel NA, Fisher RF, Gloux S, Godrie T, Goffeau A, Golding B, Gouzy J, Gurjal M, Hernandez-Lucas I, Hong A, Huizar L, Hyman RW, Jones T, Kahn D, Kahn ML, Kalman S, Keating DH, Kiss E, Komp C, Lelaure V, Masuy D, Palm C, Peck MC, Pohl TM, Portetelle D, Purnelle B, Ramsperger U, Surzycki R, Thebault P, Vandenbol M, Vorholter FJ, Weidner S, Wells DH, Wong K, Yeh KC, Batut J.
Science. 2001 Jul 27; 293(5530):668-72.
2.Characterization of the alanine racemases from two mycobacteria.
Strych U, Penland RL, Jimenez M, Krause KL, Benedik MJ.
FEMS Microbiol Lett. 2001 Mar 15;196(2):93-8
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