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D-Alanine Metabolism in S. pneumoniae R6

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Streptococcus pneumoniae (also known as Pneumococcus or Diplococcus pneumoniae) is a Gram-positive coccus and is among the most significant causes of bacterial disease in humans. It is responsible for a high proportion of cases of pneumonia, acute otitis media, acute sinusitis, bacteremia and meningitis. There are 90 known serotypes of S. pneumoniae, each of which produces a structurally different capsular polysaccharide; during infection. These serotypes function by inhibiting host complement-mediated phagocytosis. The parental S. pneumoniae strain for R6 is R36A, which is a nonencapsulated strain is derived from the capsular Type 2 clinical isolate strain D39. The pneumococcal plasma membrane is surrounded by a layer of peptidoglycan, a three-dimensional, cross-linked mesh that protects the bacterial cell from changes in osmotic [...]


1.Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.
Ng WL, Kazmierczak KM, Winkler ME.
Mol Microbiol. 2004 Aug; 53(4):1161-75.
2.Molecular characterization of the pneumococcal teichoic acid phosphorylcholine esterase.
de las Rivas B, Garcia JL, Lopez R, Garcia P.
Microb Drug Resist. 2001 Fall; 7(3):213-22.
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